Moderate Treatment Outcome with Sertraline ut not Cognitive - Behavior Therapy in Pediatric bsessive - Compulsive Disorder ohn

ackground: The presence of a comorbid tic disorder may predict a poorer outcome in the acute treatment of pediatric bsessive-compulsive disorder (OCD). ethods: Using data from the National Institute of Mental Health (NIMH)-funded Pediatric OCD Treatment Study (POTS) that ompared cognitive-behavior therapy (CBT), medical management with sertraline (SER), and the combination of CBT and ER (COMB), to pill placebo (PBO) in children and adolescents with OCD, we asked whether the presence of a comorbid tic isorder influenced symptom reduction on the Children’s Yale-Brown Obsessive Compulsive Scale (CY-BOCS) after 12 weeks of reatment. esults: Fifteen percent (17 of 112) of patients exhibited a comorbid tic disorder. In patients without tics, results replicated previously ublished intent-to-treat outcomes: COMB CBT SER PBO. In patients with a comorbid tic disorder, SER did not differ from PBO, hile COMB remained superior to CBT and CBT remained superior to PBO. onclusions: In contrast to CBT outcomes, which are not differentially impacted, tic disorders appear to adversely impact the outcome f medication management of pediatric OCD. Children and adolescents with obsessive-compulsive disorder and a comorbid tic isorder should begin treatment with cognitive-behavior therapy alone or the combination of cognitive-behavior therapy plus a erotonin reuptake inhibitor.